Yan Zhang, MD, PhD


Publications in Peer Reviewed Journals
Search papers by Yan Zhang in PubMed or Google Scholar

• 15. Goto S, Zhang Y, Vyas SA, Zhu Q, Wildsoet CF. Changes in expression in BMP2 and two closely related genes in guinea pig retinal pigment epithelium during induction and recovery from myopia. Biomolecules. 2023;13(9):1373. doi: 10.3390/biom13091373.
• 14. Goto S, Muroy SE, Zhang Y, Saijo K, Kolora SRR, Zhu Q, Wildsoet CF. Gene expression signatures of contact lens-induced myopia in guinea pig retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2022; 63. doi:https://doi.org/10.1167/iovs.63.9.25
• 13. Zhang Y*, Azmoun S, Hang A, Zeng J, Eng E, Wildsoet CF. Retinal defocus and form-deprivation induced regional differential gene expression of BMPs in chick RPE. J Comp Neurol. 2020; 528 (17): 2864-2873. doi: 10.1002/cne.24957. Pubmed (* Corresponding Author) 
• 12. Zhang Y*, Phan E, Wildsoet CF. Retinal defocus and form-deprivation exposure duration affects RPE BMP gene expression. Scientific Reports. 2019; 9:7332. doi: 10.1038/s41598-019-43574-z. Pubmed (* Corresponding Author)
• 11. Zhang Y*, Liu Y, Hang A, Phan E, Wildsoet CF. Differential gene expression of BMP2 and BMP receptors in chick retina & choroid induced by imposed optical defocus. Vis Neurosci. 2016; 33: e015. doi:10.1017/S0952523816000122. Pubmed (* Corresponding Author)
• 10. Zhang Y*, Raychaudhuri S, Wildsoet CF. Imposed optical defocus induces isoform-specific up-regulation of TGFβ gene expression in chick retinal pigment epithelium and choroid but not in neural retina. PLoS ONE. 2016; 11(5): e0155356. doi:10.1371/journal.pone.0155356. Pubmed (* Corresponding Author)
• 9. Zhang Y*, Wildsoet CF. RPE and choroid mechanisms underlying ocular growth and myopia [review]. Prog Mol Biol Transl Sci. 2015;134:221-40. Pubmed (* Corresponding Author)
• 8. Zhang Y*, Liu Y, Carol Ho, Wildsoet CF. Effects of imposed defocus of opposite sign on temporal gene expression patterns of BMP4 and BMP7 in chick RPE. Exp Eye Res. 2013; 109:98-106. Pubmed (* Corresponding Author)
• 7. Zhang Y*, Liu Y, Wildsoet CF. Bidirectional, optical sign-dependent regulation of BMP2 gene expression in chick retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2012; 53:6072-6080. Pubmed (* Corresponding Author)
• 6. Butt T, Yao W, Kaul H, Xiaodong J, Gradstein L, Zhang Y, Husnian T, Riazuddin S, Hejtmancik JF, Riazuddin SA. Localization of autosomal recessive congenital cataracts in consanguineous Pakistani families to a new locus on chromosome 1p. Mol Vis. 2007; 13:1635-40. Pubmed
• 5. Sun X, Zhang Y, Li R, Wang Z, Luo S, Gao M, Deng S, Chen W, Jin X. Acanthamoeba keratitis: clinical characteristics and management. Ophthalmology. 2006; 113:412–6. Pubmed
• 4. Sun X, Zhao H, Deng S, Zhang Y, Wang Z, Li R, Luo S, Jin X. Infectious keratitis related to orthokeratology. Ophthal Physiol Opt. 2006; 26:133–6. Pubmed
• 3. Zhang Y, Sun X, Wang Z, Li R, Luo S, Jin X, Deng S, Chen W. Identification of 18S ribosomal DNA genotype of Acanthamoeba from human with keratitis in North China. Invest Ophthalmol Vis Sci. 2004; 45: 1904-7. Pubmed
• 2. Sun X, Zhang Y, Li R, Wang Z, Luo S, Jin X, Zhang W. Etiological analysis on ocular fungal infection in the period of 1989-2000. Chin Med J. 2004; 117: 598-600. Pubmed
• 1. Sun X, Chen L, Zhang Y, Wang Z, Li R, Luo S, Jin X. Acanthamoeba keratitis as a complication of orthokeratology. Am J Ophthalmol. 2003; 136: 1159-61. Pubmed

Book Chapters

• 3. Zhang Y, Wildsoet CF. The RPE in myopia development. In: Klettner AK and Dithmar S, eds. Retinal Pigment Epithelium in Health and Disease.  1st ed. Switzerland AG: Springer; 2019: 117-138. Hardcover ISBN: 978-3-030-28383-4. eBook ISBN: 978-3-030-28384-1. 
• 2. Zhang Y, Wildsoet CF. RPE and choroid mechanisms underlying ocular growth and myopia. In: Nickerson JM and Hejtmancik JF, ed. Molecular Biology of Eye Disease. 1st ed. Philadelphia, PA: Elsevier; 2015: 221-240. ISBN: 9780128010594.
• 1. Jin X, Sun X, Zhang Y. Acanthamoeba keratitis associated with pathogenic free-living amoeba. In: Demin Han, Ningli Wang, eds. New Progress in Ophthalmology. 1st ed. Beijing: People’s Medical Publishing House; 2002; 86-100. [Chinese]

​Conference Abstracts

• 22. Goto S, Zhang Y, Wildsoet CF. Modulation of BMP2 expression in guinea pig retinal pigment epithelium during induction of and recovery from contact lens-induced myopia. Submitted to ARVO Annual Meeting 2023.
• 21. Zhang Y, Song Wu, Collins MJ, Wildsoet CF. TGF-β2 gene expression in chick RPE is differentially regulated by retinal simultaneous competing defocus of opposite sign. Invest Ophthalmol Vis Sci. 2022; 63: 1881-A0010.
• 20. Goto S, Zhang Y, Zhu Q, Wildsoet CF. Short-term induction and recovery from contact lens-induced myopia model in guinea pig. Invest Ophthalmol Vis Sci. 2022; 63: 1453-F0411.
• 19. Zhang Y, Zhu Q, Song W, Chuang GM, Sun D, Cheung K, Chou A, He A, Wildsoet CF. Dynamic BMP gene expression regulation in chick RPE during recovery from lens-induced defocus and form-deprivation. Invest Ophthalmol Vis Sci. 2021; 62: 2280.
• 18. Zhang Y, Li M, Ly A, Flannery JG, Wildseot CF. sc AAV.7M8 and VMD2 promoter as novel gene delivery tools targeting chicken RPE. Invest Ophthalmol Vis Sci. 2020; 61: 855.
• 17. Zhang Y, Azmoun S, Chhoa J, Wildsoet CF. Retinal simultaneous competing defocus of opposite sign induces up-regulation of BMP gene expression in chick RPE. Invest Ophthalmol Vis Sci. 2018; 59 (9): 752.
• 16. Wildsoet CF, Sun D, Chuang G, Zhang Y. Differential BMP gene expression persists in chick RPE following termination of retinal defocus and image degradation treatments. Invest Ophthalmol Vis Sci. 2018; 59 (9): 707.
• 15. Zhang Y, Yang W, Hang A, Zin E, Garcia M, Li M, Wildsoet CF. BMP2 protein increases the expression of genes for inhibitor of DNA binding proteins in cultured chick scleral fibroblasts. Invest Ophthalmol Vis Sci. 2017; 58 (8): 5472.
• 14. Zeng J, Zhang Y, Wildsoet CF. Culture of guinea pig corneal limbal epithelial stem cells in three different media. Invest Ophthalmol Vis Sci. 2017; 58 (8): 1116.
• 13. Zhang Y, Zhang H, Wildseot CF. Effects of defocus and image degradation on eye growth and BMP2 gene expression in chick retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2016; 57 (12): 4740.
• 12. Zhang Y, Liu Y, Ho C, Phan E, Hang A, Eng E, Wildsoet CF. BMP gene expression changes in chick RPE in response to visual manipulations. Eye and Vision. 2016; 3 (Suppl 1): 28.
• 11. Zhang Y, Eng E, Wildsoet CF. Regional differences in gene expression with imposed defocus in chick RPE. Invest Ophthalmol Vis Sci. 2015; 56 (7): 2159.
• 10. Zin EA, Zhang Y, Wildsoet CF. Identification of elements of the BMP2 signaling pathway in cultured chick scleral fibroblasts. Invest Ophthalmol Vis Sci. 2015; 56 (7): 2172.
• 9. Zhang Y, Truong A, Zhao F, Wildsoet CF. Chick retinal pigment epithelium responds to imposed defocus in minutes. Invest Ophthalmol Vis Sci. 2014;55: 3590.
• 8. Zhao F, Zhang Y, Wildsoet CF, Zeng JW. Was BMP2 involved in treatment of atropine on preventing myopic progression of chicks. International Myopia Conference 2013. Asilomar, CA
• 7. Zhang Y, Liu Y, Wildsoet CF. BMP2, BMP4, BMP7 and BMP receptor gene expression in chick retina and choroid with imposed optical defocus. International Myopia Conference 2013. Asilomar, CA
• 6. Zhang Y, Liu Y, Ho C, Hammond D, Wildsoet CF. Differential expression of BMP7, TGF-beta2, and Noggin in chick RPE after imposed optical defocus. Invest Ophthalmol Vis Sci. 2012; 53: 3458.
• 5. Zhang Y, Liu Y, Hammond D, Wildsoet CF. Possible roles of BMP2 and BMP4 in chick RPE in signaling the sign of defocus. Invest Ophthalmol Vis Sci. 2011; 52: 6320.
• 4. Zhang Y, Liu Y, Xu J, Nimri N, Wildsoet CF. Microarray analysis of RPE gene expression in chicks during long-term imposed hyperopic defocus. Invest Ophthalmol Vis Sci. 2010; 51: 3680.
• 3. Zhang Y, Maminishkis A, Zhi C, Li R, Agarwal R, Miller SS, Wildsoet CF. Apomorphine regulates TGF-β1 and TGF-β2 expression in human fetal retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2009; 50: 3845.
• 2. Zhang Z, Su J, Zhang Y, Wildsoet CF. Effect of imposed myopic defocus on the gene expression profiles in chick retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2008; 49: 1741.
• 1. Jiao X, Yao W, Riazuddin SA, Butt T, Yasmeen A, Li A, Zhang Y, Riazuddin S, Hejtmancik JF. Mutations in βB3-crystallin, Galk1, Hsf4 are associated with autosomal recessive cataract in Pakistani families. Invest Ophthalmol Vis Sci. 2007; 48: 1336.​​