Metlapally Publications 

1. Metlapally R, Jobling AI, Gentle A, McBrien NA (2006). Characterization of the integrin receptor subunit profile in the mammalian sclera. Mol Vis. 2006 Jul 6;12:725-34. PMID:16862067.
2. McBrien NA, Metlapally R, Jobling AI, Gentle A (2006). Expression of collagen-binding integrin receptors in the mammalian sclera and their regulation during myopia development. Invest Ophthalmol Vis Sci. 2006 Nov;47(11):4674-82. PMID:17065473.
3. Young TL, Metlapally R, Shay AE (2007). Complex Trait Genetics of Refractive Error. Arch Ophthalmol. 2007 Jan;125(1):38-48. PMID:17210850.
4. Metlapally R, Li YJ, Tran-Viet KN, Bulusu A, White TR, Ellis J, Kao D, Young TL (2008). Common MFRP sequence variants are not associated with moderate-high hyperopia, isolated microphthalmia and high myopia. Mol Vis 2008; 14:387-393. PMCID: PMC2268852.
5. White T*, Lu T*, Metlapally R, Katowitz J, Kherani F, Wang TY, Tran-Viet KN, Young TL (2008). Identification of STRA6 and SKI Sequence Variants in Patients with Anophthalmia/Microphthalmia. Mol Vis. 2008;14:2458-65. PMCID: PMC2610290.
6. Metlapally R, Michaelides M, Bulusu A, Li YJ, Schwartz M, Rosenberg T, Hunt DM, Moore AT, Zuchner S, Bowes Rickman C, Young TL (2009). Evaluation of the X-Linked High Grade Myopia Locus (MYP1) with Cone Dysfunction and Color Vision Deficiencies. Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1552-8. Epub 2008 Dec 20. PMID:19098318.
7. Jobling AI, Gentle A, Metlapally R, McGowan BJ, McBrien NA (2009). Regulation of scleral cell contraction by TGF-beta and stress: Competing roles in myopic eye growth. J Biol Chem. 2009 Jan 23;284(4):2072-9. PMID:19011237.
8. Ronan SM, Tran-Viet KN, Burner EL, Metlapally R, Toth CA, Young TL. Mutational hot spot potential of a novel base pair mutation of the CSPG2 gene in a family with Wagner syndrome (2009). Arch Ophthalmol. 2009 Nov;127(11):1511-9. PMCID: PMC3514888.
9. Metlapally R, Li YJ, Tran-Viet KN, Abbott D, Czaja GR, Malecaze F, Calvas P, Mackey D, Rosenberg T, Paget S, Zayats T, Owen MJ, Guggenheim JA, Young TL. COL1A1, COL2A1 Genes and Myopia Susceptibility: Evidence of Association and Suggestive Linkage to the COL2A1 Locus (2009). Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4080-6. Epub 2009 Apr 22. PMID:19387081.
10. Li YJ, Guggenheim JA, Bulusu A, Metlapally R, Abbott D, Malecaze F, Calvas P, Rosenberg T, Paget S, Creer RC, Kirov G, Owen MJ, Zhao B, White T, Mackey DA, Young TL. An International Collaborative Family-based Whole Genome Linkage Scan for High-grade Myopia (2009). Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3116-27. Epub 2009 Mar 25. PMCID: PMC3696634.
11. Yanovitch T, Li YJ, Metlapally R, Abbott D, Viet KN, Young TL. Hepatocyte Growth Factor and Myopia: Genetic Association Analyses in a Caucasian Population (2009). Mol Vis. 2009 May 20;15:1028-35. PMCID: PMC2684748.
12. Metlapally R, Ki CS, Li YJ, Tran-Viet KN, Abbott D, Malecaze F, Calvas P, Mackey DA, Rosenberg T, Paget S, Guggenheim JA, Young TL. Genetic association of insulin-like growth factor-1 polymorphisms with high-grade myopia in an international family cohort. Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4476-9. Epub 2010 Apr 30. PMCID: PMC2941166.
13. Mackey DA, Hewitt AW, Ruddle JB, Vote B, Buttery RG, Toomes C, Metlapally R, Li YJ, Tran-Viet KN, Malecaze F, Calvas P, Rosenberg T, Guggenheim JA, Young TL. Pediatric cataract, myopic astigmatism, familial exudative vitreoretinopathy and primary open-angle glaucoma co-segregating in a family. Mol Vis. 2011;17:2118-28. Epub 2011 Aug 10. PMCID: PMC3156798.
14. Abbott D, Li YJ, Guggenheim JA, Metlapally R, Malecaze F, Calvas P, Rosenberg T, Paget S, Zayats T, Mackey DA, Feng S, Young TL. An international collaborative family-based whole genome quantitative trait linkage scan for myopic refractive error. Mol Vis. 2012;18:720-9. Epub 2012 Mar 26. PMCID: PMC3324362.
15. Lim SH, Tran-Viet KN, Yanovitch TL, Freedman SF, Klemm T, Call W, Powell C, Ravichandran A, Metlapally R, Nading EB, Rozen S, Young TL. CYP1B1, MYOC, and LTBP2 mutations in primary congenital glaucoma patients in the United States. Am J Ophthalmol. 2013 Mar;155(3):508-517.e5. doi: 10.1016/j.ajo.2012.09.012. Epub 2012 Dec 4. PMCID: PMC3736560.
16. Hawthorne F, Feng S, Metlapally R, Li YJ, Tran-Viet KN, Guggenheim JA, Malecaze F, Calvas P, Rosenberg T, Mackey DA, Venturini C, Hysi PG, Hammond CJ, Young TL. Association mapping of the high-grade myopia MYP3 locus reveals novel candidates UHRF1BP1L, PTPRR, and PPFIA2. Invest Ophthalmol Vis Sci. 2013 Mar 21;54(3):2076-86. doi: 10.1167/iovs.12-11102. PMCID: PMC3621505.
17. Tran-Viet KN, Soler V, Quiette V, Powell C, Yanovitch T, Metlapally R, Luo X, Katsanis N, Nading E, Young TL. Mutation in collagen II alpha 1 isoforms delineates Stickler and Wagner syndrome phenotypes. Mol Vis. 2013 Apr 5;19:759-66. Print 2013. PMCID: PMC3626300.
18. Tran-Viet KN, Powell C, Barathi VA, Klemm T, Maurer-Stroh S, Limviphuvadh V, Soler V, Ho C, Yanovitch T, Schneider G, Li YJ, Nading E, Metlapally R, Saw SM, Goh L, Rozen S, Young TL. Mutations in SCO2 are associated with autosomal-dominant high-grade myopia. Am J Hum Genet. 2013 May 2;92(5):820-6. doi: 10.1016/j.ajhg.2013.04.005. PMCID: PMC3644634.
19. Metlapally R**, Gonzalez P, Hawthorne F, Tran-Viet KN, Wildsoet CF, Young TL. Scleral micro-RNA signatures in adult and fetal eyes. PLoS One. 2013 Oct 21;8(10):e78984. doi: 10.1371/journal.pone.0078984. eCollection 2013. PMCID: PMC3804513. (**Corresponding author)
20. Young TL, Hawthorne F, Feng S,Luo X, St.Germain E, Wang M, Metlapally R**. Whole Genome Expression Profiling of Normal Human Fetal and Adult Ocular Tissues. Exp Eye Res. 2013 Nov;116:265-78. doi: 10.1016/j.exer.2013.08.009. Epub 2013 Sep 7. PMCID: PMC3875233. (**Senior author)
21. Shen L, Melles RB, Metlapally R, Barcellos L, Schaefer C, Risch N, Herrinton LJ, Wildsoet C, Jorgenson E. The Association of Refractive Error with Glaucoma in a Multiethnic Population. Ophthalmology. 2015 Aug 7. pii: S0161-6420(15)00673-9. doi: 10.1016/j.ophtha.2015.07.002. [Epub ahead of print] PMID: 26260281.
22. Metlapally R** and Wildsoet CF. Scleral Mechanisms Underlying Ocular Growth and Myopia. Prog Mol Biol Transl Sci. 2015;134:241-8. doi: 10.1016/bs.pmbts.2015.05.005. Epub 2015 Jun 12. PMID: 26310158. (**Corresponding author)
23. Kevin K. Wang, Ravikanth Metlapally, Christine F. Wildsoet. Expression profile of the integrin receptor subunits in the guinea pig sclera. (In press, CER)
24. Metlapally R**, Park HN, Chakraborty R, Wang KK, Tan CC, Light JG, Pardue MT, Wildsoet CF. Genome-Wide Scleral Micro- and Messenger-RNA Regulation During Myopia Development in the Mouse. Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6089-6097. doi: 10.1167/iovs.16-19563. PMID: 27832275. (**Corresponding author)